Targeting Inflammation in Treated HIV, version 3.0

Peter W. Hunt, MD

A complex interaction of genetic factors, coinfections, immune activation and chronic inflammation persist throughout the course of HIV disease and contribute to the multimorbidities that complicate the management of our patients as they age. Asymptomatic CMV coinfection seems to be a particularly troublesome cofactor for many PLWH. Peter Hunt from UCSF returns with an update on the most recent research pertinent to our understanding of these complexities as they relate to aging.

HPV-positive Oropharyngeal Cancer: Pathogenesis, Epidemiology, Prevention, Diagnosis and Treatment

Anil K. Chaturvedi, Ph.D. & Scott A. Roof, MD, MS

You are probably aware that HPV is the most common STI, that HPV-16 is the most common cause of anogenital cancer, and that HPV vaccines are most effective when administered before sexual debut. But we now know that the most common cause of oropharyngeal cancer is also HPV-16, and the risk is 2 to 3 times greater in people with HIV. It is critical that we providers at the primary care level keep up to date on the prevention, early diagnosis, and appropriate specialist referral for the spectrum of HPV-related disease. This presentation by Anil Chaturvedi from the NIH, and Scott Roof from Mount Sinai addresses the etiology and impact of oropharyngeal cancer, as well as the clinical signs/symptoms, diagnosis and treatment.

Developing Sex and Gender-tailored Strategies for Healthy Aging with HIV: The Effect of Low-level Viremia and Non-AIDS Comorbidity Burden

Lauren F. Collins, MD, MSc

As our patients with HIV are aging, we are well aware of the increased risks for non-AIDS comorbidities that interfere with both quality and\or duration of life. But are there sex and gender differences that can contribute to more precision-targeted outcomes in individual patients? Don’t miss this presentation by Dr. Lauren Collins, whose clinical and research interests focus on improving the care and outcomes of persons with HIV across the lifespan, and in particular, women and those affected by the HIV/AIDS epidemic.

New Drugs for HIV Treatment and Prevention

Roy M. Gulick, MD, MPH

Throughout the history of the HIV/AIDS epidemic, the most critical advances in care and prevention have been made possible through the research and development of better and better antiretroviral treatments and strategies. As far as we have come, this basic tenet is still true as we continue the search for safer and even more effective agents. To bring us up to date, PRN is proud to welcome back Dr. Roy (Trip) Gulick for his perspective of the drug development pipeline and emerging treatment and prevention strategies.

From Hepatitis A to Zoster: 2024 Update on Immunization Recommendations for People With and At-risk for HIV

Dorothy A. Knutsen, MD

Every year we must grapple with vaccine recommendations to be sure that we are up to date in the prevention of infectious diseases for our vulnerable patient populations. In addition to routine vaccines, we must also be aware of new generations of vaccines for COVID-19 and influenza. We also have the ongoing risk of mpox, especially in gay and bisexual MSM. This year, Dr. Dorothy Knutsen will help guide us as we seek to provide the best preventive care possible.

Insights from 56 Dean Street: Europe’s Busiest STI Clinic

Gary Whitlock, MD, PhD

Rapid access to diagnosis, treatment and prevention of HIV and other sexually transmitted infections not only provides more optimal patient care to individuals, but also interrupts chains of transmission, thus benefitting the public health as well. There are many barriers to rapid access to care but the 56 Dean Street clinic in London has raised the bar higher than any other clinic in Europe, and we have much to learn from them as well. In this presentation, Dr. Gary Whitlock will share the insights that have led to their remarkable success.

More News from AIDS 2024 (Munich) on Antiretroviral Therapy, Cardiometabolic Health, and Anal Cancer Screening

Tristan J. Barber, MA, MD, FRCP

The annual conference of the International AIDS Society (IAS) is widely attended by researchers from around the world but is often hard to travel to, especially for busy clinicians. This year we will have two presentations by international thought leaders covering different aspects of the clinical track that are most useful to our audience of HIV primary care providers.

News from AIDS 2024 (Munich) on HIV Prevention and Cure, STIs, and Coinfections

Jürgen Rockstroh, MD

The annual conference of the International AIDS Society (IAS) is widely attended by researchers from around the world but is often hard to travel to, especially for busy clinicians. This year we will have two presentations by international thought leaders covering different aspects of the clinical track that are most useful to our audience of HIV primary care providers.

Raising the Bar: Updates In Organ Transplantation for People with HIV/AIDS

Sapna A. Mehta, MD, FIDSA

PRN has been following issues surrounding organ transplantation in people with HIV since it was first proposed years ago. With steady improvement in clinical outcomes, the options for people living with HIV who need organ transplantation as well as HIV-positive donors have never been better. In this program, Sapna Mehta returns with good news from transplantation through the HOPE Act, including living donor kidney transplantation from HIV-positive donors to HIV-positive recipients.

Kidney Health and Disease in People With and At-risk for HIV in the ART Era

Molly C. Fisher, DO

With the increased use in ART and PrEP in diverse populations, it is critical that we monitor kidney health for optimal outcomes and prevention of complications. We are pleased to welcome Molly Fisher for this comprehensive review of renal function, potential side effects of antiretroviral medication, the spectrum of disease associated with ART, and what you can do about it.

Mpox Now: Update on Prevention, Diagnosis & Treatment for People With or At-risk for HIV

Preeti Pathela, DrPH, MPH

Mpox is not in the news as much this year as it was when it first exploded into our awareness in 2022. But mpox is still a concern as we approach the summer months, with its constant circulation in NYC and a large outbreak overseas that poses risk for a larger resurgence in the U.S. Mpox continues to mostly affect our patients with and at-risk for HIV, especially MSM. Understanding its epidemiology and vaccinating people at risk is critical in mitigating the ongoing effects of this STI. Don’t miss this important update on mpox from Dr. Preeti Pathela from the New York City Department of Health & Mental Hygiene.

Sexually Transmitted Infections: What's New in Prevention, Diagnosis & Management

Rosalyn E. Plotzker, MD, MPH

Early diagnosis and treatment of sexually transmitted infections (STIs) are critical for people with and at-risk for HIV infection. STI vaccination for HAV, HBV, HPV, and mpox not only prevents infection but also, in the case of HBV and HPV, reduce risk of cancer. There is also promising research showing that post-exposure prophylaxis with doxycycline (doxy-PEP) can help prevent certain STIs, which may become increasingly important due to the current shortage of long-acting benzathine penicillin G. Don’t miss this dynamic update from Dr. Rosalyn Plotzker.

GLP-1 RA and SGLT2i: New Treatment Strategies for Diabetes and Obesity in the Context of HIV

Todd T. Brown, MD, PhD

With all the recent advances in the treatment strategies for obesity and for diabetes, it is hard to keep up-to-date, especially if many of your patients are already on antiretroviral regimens for HIV. This presentation by Todd Brown will help you more deeply understand how GLP-1 receptor agonists and SGLT2 inhibitors work, and their efficacy and long-term safety in the treatment of diabetes and obesity in HIV medicine.

A Closer Look at HIV and Antibody-Based Interventions for Prevention, Treatment, and Cure

Thomas J. Hope, PhD

Multi-scale imaging reveals new insights into the interactions between HIV and host immune responses that allow the virus to persist during antiviral treatment. The new technology being utilized will be described, as will the emerging insights and potential new approaches for intervention in the clinic. Don’t miss this visually dazzling presentation by Tom Hope that will help you understand infection and interventions from a nanoscopic perspective.

From Abstract to Concrete: Co-infections, Comorbidities and Complications from CROI 2024

Marshall Glesby, MD, PhD

This year we are pleased to announce that PRN will expand its coverage of CROI 2024, with Marshall Glesby focusing on other important highlights, including co-infections, comorbidities and complications.

ART Highlights from CROI 2024

Roy M. Gulick, MD, MPH

Every year, the Conference on Retrovirology and Opportunistic Infections (CROI) leads the way in the science and clinical trials of HIV treatment and prevention. Once again, PRN is proud to have Trip Gulick spotlight the most important developments in ART from CROI 2024.

Advances in Anal Cancer Prevention in People with HIV

Joel M. Palefsky, MD, FRCP (C)

PRN has long supported efforts to prevent the devastating outcomes of anal cancer in people living with HIV (PLWH). Much progress has been made through the success of the ANCHOR Study which was ended ahead of schedule due to the indisputably favorable outcomes for people receiving treatment for pre-cancerous anal lesions. This confirmation of proactive efforts to destroy high-grade squamous intraepithelial lesions in and around the anus using high-resolution anoscopy emphasizes the role that we in HIV primary care must routinely incorporate into our care for all PLWH. In this program, Dr. Joel Palefsky, the principal investigator of the ANCHOR Study, will update us on the most recent guidelines for anal cancer prevention.

Looking Beyond Bugs to Consider Drugs: Drug User Health and HIV/HCV Prevention and Treatment

Brianna Norton, DO, MPH

The principles of harm reduction in HIV medicine have been most highly driven through their empathic incorporation in strategies to minimize the harms caused by injection drug use, as exemplified by the effect of needle exchange on the reduction of HIV and HCV transmission and the evolution to HCV treatment as prevention. In this program, Dr. Brianna Norton will help prepare us to prevent, diagnose, and treat HCV coinfection and re-infection in people living with HIV as a continuous effort in harm reduction.

HIV Elite Controllers and What We’ve Learned from Them

Rajesh T. Gandhi, MD

Soon after HIV was discovered, clinicians and researchers became fascinated by a small group of people with HIV who did not progress even though they were not taking antiretroviral therapy (ART). Initially termed long-term non-progressors, some of these individuals maintain undetectable HIV RNA without taking ART and are called HIV elite controllers. In this talk, Dr. Gandhi will talk about how best to diagnose elite controllers in the era of early ART initiation and summarize the factors associated with HIV control. He will talk about the price of this control – namely immune activation and inflammation – in some elite controllers and why ART may be warranted.

HIV Post-Treatment Control: Insights On Remission from a Unique European Cohort

Asier Saez-Cirion, PhD

Antiretroviral treatment cannot eliminate HIV reservoir cells that cause viral rebound if treatment is interrupted, requiring lifelong treatment. However, some people who were diagnosed and initiated ART in the earliest stages of primary HIV infection have demonstrated the ability to stably control viremia after treatment interruption, achieving a status of durable HIV remission. Dr. Sáez-Cirión from the Institut Pasteur in Paris, France, has been studying a cohort of these rare post-treatment controllers for years in the VISCONTI Study, finding that early treatment may favor the maturation of the memory response against the virus, allowing a more efficient secondary response after treatment interruption. A better understanding of the mechanisms of post-treatment control may lead to the development of new immunotherapies to achieve HIV remission.

Empowering Cisgender Women: Inclusion and Awareness of PrEP

Shobha Swaminathan, MD, FIDSA

While much effort is utilized to promote HIV pre-exposure prophylaxis (PrEP) in gay and bisexual MSM as well as trans women, we must not diminish the critical need for PrEP for at-risk cisgender women, especially those of childbearing age. To focus on the specific needs of cisgender women, we are pleased to present Dr. Shobha Swaminathan, Director of HIV Programs at Rutgers New Jersey Medical School. Dr. Swaminathan will speak on PrEP eligibility and benefits in cisgender women, navigating the prescription process and adherence strategies for these women, as well as new PrEP options favorable to cisgender women in the pipeline.

EACS 2023: Highlights from the European AIDS Conference in Warsaw

Jürgen Rockstroh, MD

Every two years the European AIDS Clinical Society (EACS) holds its biannual conference on HIV/AIDS, coinfections, and complications, similar in many respects to the annual Conference on Retroviruses and Opportunistic Infections (CROI) in the United States.This year the EACS conference, known as EACS 2023, will be held in Warsaw, Poland. We are fortunate to have Juergen Rockstroh, the current EACS guidelines chair, report to PRN on the highlights of this important international conference, including an update on the evolving epidemiology in Europe, the challenges around HIV care in migrant populations, new data on ART, as well as updates on HIV comorbidities and aging.

2023 Update on Immunization Recommendations for Individuals With and At-risk for HIV Disease

Denise H. Benkel, MD, MPH

Preventive measures, including prophylaxis, have always been a critical part of HIV medicine. Vaccines play a special role as a scalable modality to reduce epidemic diseases worldwide. In our current times we must rebut misinformation about vaccine safety and efficacy to keep our patients fully updated with the immunizations they need to maintain optimal health. When our patients return for routine HIV or PrEP follow-up, we all have an ideal opportunity to evaluate and encourage recommended vaccines. Please join us for this update by Dr. Denise Benkel from the NYC DOH Bureau of Immunization about what we can do now. There is no time to lose!

Update on Hepatitis B and D in People With or At-Risk for HIV Coinfection

Debika Bhattacharya MD, MSc

The risks for hepatitis B and D lurk in the background for anyone with or at-risk for HIV. It is particularly important to keep this in mind when patients initiate or change medications for HIV and PrEP. Of course, we have had safe and effective vaccinations to prevent hepatitis B for many years, but for patients who have a history of hepatitis B, and are therefore at risk for hepatitis D, additional monitoring is necessary, and extra caution is advised when changing HIV treatment or prevention strategies, to guard against hepatic flare or rebound.  In this important program, Dr. Debika Bhattacharya. the Chair of the Hepatitis Transformative Science Group (TSG) within the AIDS Clinical Trials Group (ACTG), will address these issues and provide updates in the management of hepatitis B and D.

Towards an HIV Cure: Understanding HIV Persistence and Therapeutic Approaches

Sharon R. Lewin, AO, FRACP, PhD, FAA, FAHMS

HIV cure has been limited to only a few cases over the past couple decades, starting with the Berlin Patient, but what is needed is a safer and scalable cure aimed at far broader populations of people living with HIV. This year, the International AIDS Society focused on HIV cure research from around the world at IAS 2023. We are fortunate to have Dr. Sharon Lewin, the current President of the IAS, who presided over IAS 2023, speak on this critical area of research so that one day we may hopefully be able to transform HIV from a manageable to a curable disease.

Treatment Challenges of Multi-Drug Resistant HIV-1 Infection

M. Ali Rai, MD, PhD

On a recent survey, approximately one-third of our audience responded that they have patients with multi-drug resistant (MDR) HIV-1, which was higher than we anticipated. Although we hope the absolute number of patients failing therapy is small, this statistic underscores the reality that a significant number of us need to continue searching for new treatment options/classes/strategies that can serve the needs of our most vulnerable patients. PRN continues to spotlight emerging treatment research, and we are pleased to continue this effort with Dr. Ali Rai, from the National Institute of Allergy and Infectious Diseases (NIAID), who will help us understand the dimensions of the current challenge, utilize the most up-to-date methods for determining HIV resistance, and ways that you can help your patients access research studies for novel treatment modalities.

Clinical Research Highlights from IAS 2023

James McMahon, MD

Every other year the International AIDS Society holds its scientific meeting, and this year the meeting is in Brisbane, Australia. We are extremely fortunate to have Dr. James McMahon, Lead of the Clinical Science Committee (Track B) at IAS 2023, present the highlights of this important conference to our PRN audience. Dr. McMahon is also the current Vice President and President-Elect for Australasian Society for HIV, Viral Hepatitis and Sexual Health Medicine. If you’re not planning to travel to Brisbane, PRN is delighted to bring Dr. McMahon’s perspective to you!

What is Chemsex? Epidemiology, Harms & Impacts

Gary Whitlock, MD, PhD

Chemsex is something we don’t often talk about, but it plays a critical role in the spread of HIV and other STIs. Dr. Gary Whitlock is Service Director at 56 Dean Street, a sexual health clinic in the heart of London’s Soho, specialising in reducing infections and promoting sexual wellbeing amongst the LGBTQI+ community, and an international leader in dealing with this important challenge to clinical care and harm reduction. We hope that this presentation will be of help to you in coping with some of the most difficult barriers that our patients face.

Update on HIV-1 bNAbs for the Prevention, Therapy, and Cure of HIV

Marina Caskey, MD

Anti-HIV broadly neutralizing antibodies (bNAbs), alone or in combination, are some of the most exciting agents in the pipeline for the prevention, management, salvage, and potential cure of HIV. Dr. Marina Caskey, one of the most prominent researchers leading the way in this new field of immunotherapy, returns with an update on bNAbs in clinical development, and results from HIV-prevention trials utilizing bNAbs.

Kaposi Sarcoma and KSHV Transmission in MSM and Other High Risk Groups

Sheena M. Knights, MD

Although we see Kaposi Sarcoma less frequently these days, it is far from gone, as we know from seroprevalence data for the causative virus, KSHV. We have had numerous talks at PRN over the past 30 years on the discovery of KSHV and the evolving therapies for the manifestations of KS. Now it is time to focus again on the silent sexual transmission of this infection and a reminder of the various manifestations of this disease in people living with HIV. In this presentation, Sheena Knights will share her recent research in the ongoing spread of KSHV in at-risk populations and health disparities that may still contribute to mortality among MSM with HIV.

Update on Mpox and Preventing Future Outbreaks

Preeti Pathela, DrPH, MPH

The explosion of mpox that caught everybody by surprise and most severely affected our immunodeficient patients has receded, but is not gone. It is important now that mpox be included in our pantheon of sexually transmitted infections and include necessary preventive immunization for our patients at risk moving forward.

Sexual Transmission of HCV Among MSM

Daniel S. Fierer, MD

For men who have sex with men and for transgender women who have sex with men, acute or primary hepatitis C has been shown to be a sexually transmitted infection. Similarly, HCV reinfection has been shown to be sexually transmitted as well. It is of critical importance that we keep this in mind for our patients on PrEP to prevent HIV infection, as well as our patients living with HIV. In this presentation, Daniel S. Fierer explains the risks, the incidence, early diagnosis, and treatment strategies for both HCV primary infection and reinfection.

Body Fat Changes with Aging in People with HIV: Implications for Healthspan and Lifespan

Todd T. Brown, MD, PhD

Aging with HIV disease is often accompanied by bothersome body fat changes that affect our patients’ self-images. But fat depots also have variable effects on health outcomes that we need to understand in order to best serve our aging patient population.

Update on Inflammation, Aging, and CMV Co-Infection in Treated HIV

Peter W. Hunt, MD

Immune activation and chronic inflammation persist throughout the course of HIV disease and contribute to the multimorbidities that complicate the management of our patients as they age. CMV coinfection seems to be a particularly troublesome cofactor for many PLWH. Peter Hunt returns with an update on the most recent research pertinent to understanding these complexities as they relate to aging.

Getting to the Heart of the Matter: Updates on Cardiovascular Disease in HIV

Mabel Toribio, MD

Cardiovascular disease is an ongoing problem in HIV management. We are pleased that Mabel Toribio is able to provide an update for cisgender and transgender men and women with or at risk for CVD.

Updates From CROI 2023

Roy M. Gulick, MD, MPH

Trip Gulick returns to PRN to spotlight key research from the Conference on Retrovirology and Opportunistic Infections (CROI).  Dr Gulick will target the latest advances in HIV treatment, and prevention, as well as other pandemic diseases reported at the recent CROI 2023.  CME and MOC are available.

Non-AIDS-Defining Cancers in People Living with HIV

Keith M. Sigel, MD, PhD, MPH

Thanks to the benefits of antiretroviral therapy, we rarely see AIDS-defining cancers in people living with HIV. Yet as our patients age, they are at higher risk for other cancers and Dr. Keith Sigel will bring us up to date on screening, diagnosis, and treatment of non-AIDS-defining cancers in PLWH.

Black Lives (with HIV) Matter: Dismantling Systemic Racism to End the HIV Epidemic Among Black MSM

Ofole Mgbako, MD

It is vital for HIV clinicians to focus on the ongoing inequities in health care that our Black and brown patients continue to face today. Dr. Ofole Mgbako will help us recognize the ongoing nuances of systemic racism in HIV care, appreciate its historical roots, and consider potential strategies to dismantle systemic racism along the HIV care continuum.

How to Manage a Pandemic: Science, Public Health and Culture

William M. Valenti, MD

The international spread of infectious diseases challenges our daily medical practices, our hospital capabilities, patient perception of public health priorities and the moving target of scientifically driven responses. Starting with HIV, we had to overcome stigma to fight for a unified and worldwide response which is ongoing. That infrastructure has contributed significantly to our subsequent responses to viral hepatitis, and most recently COVID-19 and monkeypox.

Highlights from HIV Glasgow 2022: What Was New and Exciting?

Jürgen Rockstroh, MD

HIV Glasgow is an important biennial international meeting on HIV drug therapy and related issues including coinfections, other epidemic diseases and the effects of war in Europe. Don’t miss this timely update by Jürgen Rockstroh which will also include the most recent changes in HIV treatment guidelines in the UK and Europe.

Prevention Strategies for Immune Compromised Individuals

Angélica Cifuentes Kottkamp, MD

While precautions against disease transmission have been reduced in public gathering spaces, current recommendations for the general population do not really address the extra precautions and strategies necessary to protect our most vulnerable immune-compromised patients, including those with immune failure from HIV/AIDS and immune suppression from transplants or cancer chemotherapy. Understanding the unique needs of such patients as well as vaccine limitations and safety precautions are critically important to the well-being, quality of life, and survival of the immune-compromised. Don’t miss this important presentation by Angélica Cifuentes Kottkamp that dives into the details.

Updates from IDWeek 2022 on HIV, Monkeypox and COVID-19

Rajesh T. Gandhi, MD

IDSA’s annual conference, IDWeek, is always a rich source of research information that pertains to our patient populations. This year, Raj Gandhi will focus on highlights from IDWeek on HIV, MPXV, and COVID-19. Don’t miss this important and timely update!

STImulating Sexual Health Updates: Diagnosis & Management of Sexually Transmitted Infections

Rosalyn E. Plotzker, MD, MPH

Our knowledge of, and clinical skills in diagnosis of, sexually transmitted infections are constantly evolving. It is critical that we are up to date on all of the STIs because patients often with more than one at a time. Culturally sensitive sexual histories and physical exams are critical for early diagnosis and treatment for interrupting chains of transmission in the communities that we serve. Don’t miss this STImulating update by Rosalyn Plotzker.

Diverse Case Presentations of Monkeypox in NYC

Dennis M. Feihel, MD and Peter J. Meacher, MD and Baturalp Baserdem, MD and Jonathan Baker, PA-C

Monkeypox crashed into our communities earlier this year spreading like wildfire, especially in sexually active MSM. There were many diverse clinical presentations, so we have brought together a panel of NYC primary care providers to share their experiences in diagnosing this new sexually transmitted infection.

Predicting Success and Failure on Long-acting Cabotegravir/Rilpivirine

Daniel R. Kuritzkes, MD

Is long-acting cabotegravir/rilpivirine 100% effective? Not quite. Though relatively rare, there are measurable factors that, when present, are independent predictors of virologic failure in people on treatment with injectable, CAB/RPV LA for HIV disease. Dr. Kuritzkes, a long-time thought leader in HIV treatment success and failure, dives into the details.

2022 Update on Immunization Recommendations for Individuals With and At-risk for HIV Disease

Jane R. Zucker, MD, MSc, FIDSA

Immunizations are our best bet for combatting preventable disease in all people, young and old. And in our patients with and at-risk for HIV infection, immunizations have never been more important than in the topsy-turvy world of infectious diseases we are living through! Dr. Jane Zucker returns with critical updates to current vaccine recommendations in adults and adolescents and Dr. Tristan McPherson will add updates on current monkeypox (MPX) prevention strategies.

Highlights from the 24th International AIDS Conference: Montreal 2022

W. David Hardy, MD, AAHIVS

This program presented by David Hardy is a review of highlights from AIDS 2022: the live 24th International AIDS Conference in Montreal, Canada, including clinically relevant advances in antiretroviral therapy and PrEP, emerging adverse effects, as well as new agents for HIV treatment and prevention.

Monkeypox Epidemic Outside of Endemic Regions: Experience from the UK & Europe

Sanjay R. Bhagani, MD

The last thing we need is another pandemic, but it looks like that is what is happening with Monkeypox (MPX), especially in men who have sex with men (MSM). This epidemic outside of endemic regions of Africa was first noted in England and other parts of Europe. Now that this infection is exploding in the United States, we have invited Sanjay Bhagani from the Royal Free in London to speak on his experiences dealing with MPX from the very beginning.

Impact of COVID-19 on HIV and HCV Screening and Lessons Learned for 2022

Martin Hoenigl, MD, FECMM

We all know how COVID-19 has upended health care since 2020 but how much has it affected HIV and HCV screening, diagnosis, and treatment? How can we get back on track in 2022? Don’t miss this thought-provoking presentation by Martin Hoenigl.

PET Imaging Provides Novel Insights Into HIV/SIV and SARS-CoV-2 Disease Progression

Thomas J. Hope, PhD

We have seen the dazzling and thought-provoking images from Tom Hope in the past and in this new presentation we will see further advances from macro- to micro-imaging that reveal progression of SIV and SARS-CoV-2 infection in non-human primate models. His recent research focuses on HIV-related mucosal immunology, HIV transmission and prevention science, as well as infection-related disease progression for COVID-19 and long COVID.

HIV Remission in a Woman of Mixed Race with AML and HIV: The New York Patient

Marshall Glesby MD, PhD and Deborah Persaud, MD, PhD

First there was the Berlin patient, then the London patient, and now, we have the New York patient who is a mixed-race cisgender woman cured of HIV.  There are other important differences between this new cure including the use of cord blood in her stem cell transplant.  Don’t miss this important description of her case, as presented by Drs. Marshall Glesby and Deborah Persaud.

Weight Gain and Obesity in People with HIV

Todd T. Brown, MD, PhD

What is the current impact of antiretroviral therapy on weight gain?  And how do weight gain and adipose distribution effect clinical outcomes in people living with HIV?  Todd Brown provide a comprehensive review of the current evidence, as well as optimal approaches to weight gain prevention and treatment in PLWH.

Long COVID in People With and Without HIV

Keri N. Althoff, PhD, MPH

What are the post-acute sequelae of SARS-CoV-2 that define long COVID? Is it different in people living with HIV? This presentation by Keri Althoff will help you understand the phenotypes and possible mechanisms of long COVID. Dr. Althoff will also focus on the manifestations of long COVID in people living with HIV.

Prostate Cancer in Cisgender Gay and Bisexual Men and Trans Women

Channa A. Amarasekera, MD

Is the experience of diagnosis and treatment of prostate cancer different in gay and bisexual men than it is in straight men?  Dr. Channa Amarasekera, the director of the first Gay and Bisexual Men’s Urology Program in the country, thinks so. In this important presentation, you will learn about his efforts to improve the urologic care experience, outcomes and quality of life for cisgender men who identify as gay or bisexual.  You will also appreciate how HIV infection influences prostate cancer screening and treatment.

Preventing Anal Cancer: Results from the ANCHOR Study

Joel M. Palefsky, MD, FRCP (C)

We have known for a long time that the incidence of anal cancer associated with HPV infection is higher amongst people living with HIV. But now, with the results of the ANCHOR study, we know that identification of anal high-grade squamous intraepithelial lesions (HSIL) through high resolution anoscopy (HRA) followed by destruction of these pre-cancerous lesions has been proven to prevent progression to anal cancer. In this presentation, Joel Palefsky returns to PRN to share the exciting results of the ANCHOR study and its implications for a new standard of care in people living with HIV.

CROI 2022: Updates on HIV Treatment & Prevention and SARS-COV-2

Roy M. Gulick, MD, MPH

Every year the Conference on Retrovirology and Opportunistic Infections (CROI) is packed with important new information in HIV medicine and again this year includes COVID-19 as well. Don’t miss this engaging review by Trip Gulick on CROI 2022 highlights in HIV cure, new drugs, treatment strategies and prevention, as well as the latest on SARS CoV-2 and COVID-19.

Healthy Aging with HIV in the Context of COVID-19

Giovanni Guaraldi, MD

When you really think about it, healthy aging is the ultimate goal of HIV management.  In the context of polypharmacy so often seen in older people, and in the midst of the the COVID-19 pandemic, Giovanni Guaraldi will help you understand the principles of HIV geriatric medicine, assess biological age with frailty, appreciate different models of HIV care in older adults, and maintain optimal antiretroviral therapy while deprescribing polypharmacy.

Healthy Aging with HIV in the Context of COVID-19

Giovanni Guaraldi, MD

When you really think about it, healthy aging is the ultimate goal of HIV management.  In the context of polypharmacy so often seen in older people, and in the midst of the the COVID-19 pandemic, Giovanni Guaraldi will help you understand the principles of HIV geriatric medicine, assess biological age with frailty, appreciate different models of HIV care in older adults, and maintain optimal antiretroviral therapy while deprescribing polypharmacy.

HIV Testing: Time for a Change, and the Reasons Why

Bernard M. Branson, MD

Pre-exposure prophylaxis, especially long-acting PrEP, affects the laboratory diagnosis of HIV.  And the current diagnostic algorithm needs some updating anyway. In this presentation, Bernie Branson discusses the aging HIV diagnostic algorithm and ways to improve it, the difference between HIV RNA for diagnosis vs. monitoring, and which tests are necessary before initiating ART.

Updates on COVID-19 Treatment and HIV/COVID-19 Coinfection

Rajesh T. Gandhi, MD

Evidence-based treatment options for COVID-19 in non-hospitalized patients are expanding. In this presentation Raj Gandhi will discuss the most current approaches to treating non-hospitalized patients with COVID-19, as well as important considerations for hospitalized patients.  Additionally, Dr. Gandhi will summarize our current understanding of COVID-19 in people living with HIV.