PET Imaging Provides Novel Insights Into HIV/SIV and SARS-CoV-2 Disease Progression
Thomas J. Hope, PhD
Professor, Departments of Cell and Molecular Biology
Obstetrics and Gynecology, and Biomedical Engineering
Feinberg School of Medicine
Northwestern University, Chicago, IL
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Thomas J. Hope received his Ph.D. from the University of California, Berkeley, Department of Immunology, where he studied Molecular Immunology under Dr. H. Sakano. He completed his postdoctoral training at the University of California, San Francisco where he studied the HIV Rev protein.
Dr. Hope’s laboratory at Northwestern University has pioneered the use of cell biology approaches to study HIV providing images and movies of HIV interacting with cells and tissues. For the past 25 years, his research has focused on HIV Cellular Virology. More recently, this focus has expanded to HIV related mucosal immunology, HIV transmission, and HIV prevention science.
His work has been published over the past three decades in respected journals such as Science, PNAS, The Journal of Cell Biology, Cell Host and Microbes, Journal of Virology, and PLoS Pathogens. Dr. Hope is also the Editor-in-Chief of AIDS Research and Human Retroviruses and a Section Editor for PLoS Pathogens. Dr. Hope is a widely respected speaker and gives talks about his innovative work on AIDS/HIV at many institutions and conferences, nationally and internationally.
At the completion of this educational session, learners will:
1. Appreciate the utilization of longitudinal PET/CT-scans, combined with multiple imaging modalities at different scales (multiscale imaging), to study infection associated disease progression for SIV and SARS-CoV-2.
2. Recognize the dynamics of virus expression as revealed by the PET/CT signal of 64Cu-labelled SIV probe after ART initiation, long-term ART treatment, and after analytical therapy interruption (ATI). Describe the characteristics of sites of increasing PET/CT signal detected after ATI.
3. Be aware of the results of initial studies with a SPIKE targeted 64Cu-FAB2 probe in SARS-CoV-2 infected rhesus macaques.
Policies and standards of the Medical Society of the State of New York and the Accreditation Council for Continuing Medical Education require that speakers and planners for continuing medical education activities disclose any relevant financial relationships they may have with commercial interests whose products, devices, or services may be discussed in the content of a CME activity.
- Dr. James F. Braun (Course Director) has no relevant financial relationships to disclose.
- Dr. William M. Valenti (Moderator) has no relevant financial relationships to disclose.
- Dr. Thomas J. Hope (Presenter) has no relevant financial relationships to disclose. Dr. Hope submitted their slides in advance for adequate peer review and will support their presentation and clinical recommendations with the best available evidence from the medical literature.
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