Therapeutic Strategies Aimed at Achieving Antiretroviral Drug-Free HIV Remission
Tae-Wook Chun, PhD
Chief, HIV Immunovirology Unit
Earl Stadtman Investigator at NIAID/NIH, Bethesda, MD
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Tae-Wook Chun received his Ph.D. from the Biochemistry, Cellular, and Molecular Biology Graduate Program from the Johns Hopkins University School of Medicine where he discovered and characterized latently infected, resting CD4+ T cells in HIV-infected individuals. He then pursued postdoctoral work at the NIH, where he demonstrated that latent HIV reservoir persists in virtually all infected individuals receiving antiretroviral therapy despite effective suppression of plasma viremia, and that early initiation of antiretroviral therapy leads to a decay of the latent viral reservoir. He is currently the Earl Stadtman Investigator at NIAID/NIH and continues to study the role of viral reservoirs in the pathogenesis of HIV disease and is working towards developing therapeutic strategies aimed at achieving sustained virologic remission in infected individuals without antiretroviral therapy.
At the completion of this educational session, learners will:
- Understand the impact of analytical treatment interruption on immunologic and virologic parameters in HIV-infected individuals.
- Know the outcome of recent therapeutic clinical trials aimed at achieving sustained virologic remission in HIV-infected individuals in the absence of antiretroviral therapy.
- Be aware of an on-going clinical trial being conducted at the National Institute of Allergy and Infectious Diseases involving two HIV-specific broadly neutralizing antibodies.
This PRN CME activity is funded in part by unrestricted educational grants from:
Gilead Sciences; Janssen Therapeutics, a division of Janssen Products, LP; and Merck & Co.
