Perspectives on Therapeutic Interventions Aimed at Eradicating HIV
Tae-Wook Chun, PhD
Associate Scientist, Laboratory of Immunoregulation
Michael C. Sneller, MD
Medical Officer, Laboratory of Immunoregulation
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD
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At the completion of this educational session, learners will:
- Better understand the mechanism by which HIV reservoirs persist in infected individuals receiving antiretroviral therapy.
- Understand current therapeutic strategies aimed at eradicating HIV in infected individuals receiving antiretroviral therapy.
- Be aware of a newly initiated therapeutic HIV vaccine clinical trial and patient recruitment.
Tae-Wook Chun received his PhD in Biochemistry, Cellular, and Molecular Biology from Johns Hopkins University School of Medicine. In 1997, he identified and characterized latently infected, resting CD4+ T cells in HIV-infected individuals. He then pursued postdoctoral work at the NIH, where he demonstrated that latent HIV reservoir persists in virtually all infected individuals receiving antiretroviral therapy despite effective suppression of plasma viremia, and that early initiation of antiretroviral therapy leads to a decay of the latent viral reservoir. He is currently an Associate Scientist at the NIH and continues to study the role of viral reservoirs in the pathogenesis of HIV disease and is working towards developing therapeutic strategies aimed at achieving sustained virologic remission in infected individuals without antiretroviral therapy.
Dr. Michael Sneller received his M.D. degree from the University of Kansas School of Medicine, and completed residency in Internal Medicine at Duke University. He came to the National Institutes of Health in 1983, joining the NIAID’s Laboratory of Clinical Investigation where he completed a research and clinical fellowship in Infectious Diseases. He is currently a Medical Officer in the NIAID Laboratory of Immunoregulation where he conducts clinical research in HIV and Heptatitis C infections.
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