Inflammation, Morbidity and Mortality in Treated HIV: Roles of Asymptomatic CMV and Sex Differences
Peter W. Hunt, MD
Professor of Medicine, Division of Experimental Medicine, UCSF
Co-Director of Basic/Translational Sciences, Center for AIDS Research
San Francisco, CA
Videos of live meetings of PRN in NYC are owned and published by Physicians’ Research Network, Inc. Copyright © 2021. All rights reserved.
Peter Hunt’s primary research focus is on the inflammatory consequences of HIV infection. His translational research program seeks to understand both the causes and consequences of persistent immune activation in treated HIV infection, including its impact on age-related morbidity and mortality as well as HIV persistence. He also conducts pilot clinical trials of novel immune-based interventions designed to decrease immune activation and recently completed a term as Chair of the Inflammation Committee of the AIDS Clinical Trials Group (ACTG). His laboratory’s more recent work has focused on the impact of the inflammatory state on vaccine responsiveness and on the contribution of asymptomatic CMV infection to multiple inflammatory pathways in treated HIV infection. This latter work has led to a large clinical trial in the ACTG (A5383) and multiple linked NIH grants.
At the completion of this educational session, participants will:
1. Understand the potential impact of asymptomatic CMV and other herpesvirus replication on the inflammatory state in treated HIV infection.
2. To understand the potential contributions of CMV-associated inflammation to end organ disease in treated HIV infection and the landscape of planned clinical trials that will shed light on these issues.
3. To understand sex differences in the inflammatory state in treated HIV infection and how they may impact morbidity risk.
Policies and standards of the Medical Society of the State of New York and the Accreditation Council for Continuing Medical Education require that speakers and planners for continuing medical education activities disclose any relevant financial relationships they may have with commercial interests whose products, devices, or services may be discussed in the content of a CME activity.
- Dr. James F. Braun, DO (Course Director) has no relevant financial relationships to disclose.
- Dr. William M. Valenti (Moderator) has no relevant financial relationships to disclose.
- Dr. Peter W. Hunt (Presenter) has no relevant financial relationships to disclose. Dr. Hunt will support his presentation and clinical recommendations with the best available evidence from the medical literature and will submit his slides in advance for adequate peer review.
Download Article PDF/Slides