HPV-positive Oropharyngeal Cancer: Pathogenesis, Epidemiology, Prevention, Diagnosis and Treatment

Anil K. Chaturvedi, Ph.D.
Senior Investigator, Clinical Epidemiology Unit, Clinical Genetics Branch
Senior Advisor for Faculty Development
Division of Cancer Epidemiology and Genetics
National Cancer Institute, National Institutes of Health
Rockville, MD

Scott A. Roof, MD, MS
Assistant Professor
Director of Clinical Research
Division of Head and Neck Oncology and Microvascular Surgery
Department of Otolaryngology - Head and Neck Surgery
Icahn School of Medicine at Mount Sinai, New York, NY

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CME VIDEO

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About the Presenter:

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Dr. Chaturvedi is a Senior Investigator and Senior Advisor for Faculty Development, Division of Cancer Epidemiology and Genetics, US National Cancer Institute. Dr. Chaturvedi’s research program addresses the molecular epidemiology of HPV-associated oropharyngeal cancers and oral cavity cancers. His research spans etiology, natural history, biomarkers, risk stratification, screening, and prevention of these cancers. Dr. Chaturvedi’s work has shown HPV infection as the cause of recent increases in oropharyngeal cancer incidence in the United States, characterized the epidemiology of oral HPV infection and HPV-positive oropharyngeal cancer in the US population, and evaluated the population-level efficacy of HPV vaccines for prevention of these cancers. His current work is characterizing optimal age limits for HPV vaccination of US men and the potential utility of screening for early detection of HPV-positive oropharyngeal cancers. Dr. Chaturvedi’s research on oral cavity cancers aims to characterize oral carcinogenesis at the macroscopic, microscopic, molecular/genomic, and microbiomic levels to inform secondary prevention and early detection. His work addresses foundational questions pertaining to oral cavity cancer screening—who to screen, how to conduct screening, how to clinically manage screen-positive individuals, and if and how population-wide screening could be implemented. With collaborators in Taiwan, India, and the United States, Dr. Chaturvedi has conducted comprehensive molecular epidemiologic studies to characterize the natural history of oral precancer, screening modalities for oral precancer/cancer, and risk stratification tools for triage of individuals for screening and clinical management.

Dr. Scott Roof serves as the Director of Clinical Research and an Assistant Professor in the Department of Otolaryngology - Head and Neck Surgery at the Icahn School of Medicine at Mount Sinai. As a clinician, Dr. Roof treats patients with head and neck cancer, ranging from thyroid cancer, to larynx cancer, to HPV-associated Oropharynx Cancer, which is the focus of his talk. In his role as Director of Clinical Research, Dr. Roof leads a comprehensive clinical research program focused on advancing head and neck oncology, with a particular emphasis on innovations in microvascular surgery and the use of circulating tumor DNA, or liquid biopsies, for the treatment of HPV-associated cancers. His work is widely published in high-impact journals, covering breakthroughs in surgical techniques and novel treatment adaptations, including studies that inform and refine clinical guidelines for HPV-associated oropharyngeal carcinoma. As dedicated educator, he also mentors’ medical students and residents, guiding the next generation of clinicians and researchers through rigorous training in surgery and clinical research.

Learning Objectives:

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At the completion of this educational activity learners will:
1. Appreciate the burden and risk of oral HPV infection and HPV-positive oropharyngeal cancer
2. Understand current tools for prevention of HPV-positive oropharyngeal cancers
3. Know the clinical manifestations of, and diagnostic work-up for oropharyngeal cancer.
4. Understand the management and treatment options that are currently available.

CME Information:

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This CME activity has approved for AMA PRA Category 1 Credit™ for November 19, 2024, as a live activity. This activity will also be available as an enduring activity from November 26, 2024, through November 18, 2027.

The target audience is all physicians, NPs and PAs involved or interested in HIV education.

This online video and post-activity evaluation are one hour in length.

Accreditation Statement:

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This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of the Medical Society of the State of New York (MSSNY) and the Physicians’ Research Network (PRN). MSSNY is accredited by the ACCME to provide continuing medical education for physicians.

The Medical Society of the State of New York designates this enduring material for a maximum of 1.0 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

ABIM MOC Recognition Statement:

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Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1 Medical Knowledge MOC points in the American Board of Internal Medicine’s (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider’s responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit.

Disclosure Statement:

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Policies and standards of the Medical Society of the State of New York and the Accreditation Council for Continuing Medical Education require that speakers and planners for continuing medical education activities disclose any relevant financial relationships they may have with commercial interests whose products, devices, or services may be discussed in the content of a CME activity.
- Dr. James F. Braun (Course Director/Planner) has no relevant financial relationships to disclose.
- Dr. Joseph P. McGowan, MD (Moderator) has no relevant financial relationships to disclose.
- Dr. Anil K. Chaturvedi, Ph.D. (Presenter) has no relevant financial relationships to disclose. Dr. Chaturvedi submitted his slides in advance for adequate peer review and supported his presentation and clinical recommendations with the best available evidence from the medical literature.
- Dr. Scott A. Roof, MD MS (Presenter) has no relevant financial relationships to disclose. Dr. Roof submitted his slides in advance for adequate peer review and supported his presentation and clinical recommendations with the best available evidence from the medical literature.

Financial Support:

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This PRN CME activity is funded in part by unrestricted educational grants from Gilead Sciences and ViiV Healthcare and by a generous charitable contribution from Northwell Health Center for AIDS Research & Treatment.