HIV Immune Reconstitution Inflammatory Syndrome: Pathogenesis and Pearls for Clinical Management
David R. Boulware, MD, MPH, CTropMed
Lois & Richard King Distinguished Assistant Professor
Associate Director of Global Health Programs in Internal Medicine,
Division of Infectious Diseases & International Medicine,
Department of Medicine, University of Minnesota, Minneapolis, MN
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At the completion of this educational session, participants should be able to:
- Recognize risk factors for immune reconstitution inflammatory syndrome (IRIS).
- Distinguish IRIS from other mimics.
- Understand clinical management and treatment of IRIS.
Davis Boulware serves as the Associate Director of Global Health Programs in Internal Medicine at the University of Minnesota, and his research interest is in understanding the pathogenesis of HIV immune reconstitution inflammatory syndrome (IRIS). In particular, Dr. Boulware is most interested in translational research of disease pathogenesis leading to practical clinical interventions to improve outcomes. In collaboration with investigators at Makerere University and Mbarara University in Uganda, and at the University of Cape Town, in South Africa, Dr Boulware is working to improve the survival of persons with cryptococcal meningitis by identifying the optimal time to start HIV therapy after meningitis (NCT01075152). Through this trial, Dr. Boulware’s collaborative research involves characterizing the differences in immune responses that occur over time among people who develop IRIS, in an effort to identify the pathophysiology of IRIS, identify biomarkers for the prediction and diagnosis of IRIS, develop better treatments, and to prevent IRIS.
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