PRN Meeting: November 19, 2024 Jointly provided by the Medical Society of the State of New York, at a Zoom webinar, 7:00 p.m. to 9:00 p.m (EST).

Target Audience:

Physicians, Nurse Practitioners, and Physician Assistants caring for people at risk for, or infected with HIV and/or viral hepatitis.

Course Director: James F. Braun, DO, President & Program Planner, Physicians' Research Network

Moderator: Joseph P. McGowan, MD, FACP, FIDSA, Professor, Inst. of Health System Science, Feinstein Inst. for Medical Research, Zucker School of Medicine, Hofstra/Northwell

Guest Speakers and Presentations:

HPV-positive Oropharyngeal Cancer: Pathogenesis, Epidemiology, Prevention, Diagnosis and Treatment

Anil K. Chaturvedi, Ph.D.
Senior Investigator, Clinical Epidemiology Unit, Clinical Genetics Branch
Senior Advisor for Faculty Development
Division of Cancer Epidemiology and Genetics
National Cancer Institute, National Institutes of Health
Rockville, MD

Scott A. Roof, MD MS
Assistant Professor
Director of Clinical Research
Division of Head and Neck Oncology and Microvascular Surgery
Department of Otolaryngology - Head and Neck Surgery
Icahn School of Medicine at Mount Sinai

You are probably aware that HPV is the most common STI, that HPV-16 is the most common cause of anogenital cancer, and that HPV vaccines are most effective when administered before sexual debut. But we now know that the most common cause of oropharyngeal cancer is also HPV-16, and the risk is 2 to 3 times greater in people with HIV. It is critical that we providers at the primary care level keep up to date on the prevention, early diagnosis, and appropriate specialist referral for the spectrum of HPV-related disease. This presentation by Anil Chaturvedi from the NIH, and Scott Roof from Mount Sinai addresses the epidemiology and impact of oropharyngeal cancer, as well as the clinical signs/symptoms, diagnosis and treatment.

At the completion of this educational activity learners will:
1. Appreciate the burden and risk of oral HPV infection and HPV-positive oropharyngeal cancer
2. Understand current tools for prevention of HPV-positive oropharyngeal cancers
3. Know the clinical manifestations of, and diagnostic work-up for oropharyngeal cancer.
4. Understand the management and treatment options that are currently available.

Targeting Inflammation in Treated HIV, version 3.0

Peter W. Hunt, MD

Professor of Medicine, Division of Experimental Medicine, UCSF
Co-Director of Basic/Translational Sciences, Center for AIDS Research
San Francisco, CA

A complex interaction of genetic factors, coinfections, immune activation and chronic inflammation persist throughout the course of HIV disease and contribute to the multimorbidities that complicate the management of our patients as they age. Asymptomatic CMV coinfection seems to be a particularly troublesome cofactor for many PLWH. Peter Hunt from UCSF returns with an update on the most recent research pertinent to understanding these complexities as they relate to aging.

At the completion of this educational activity learners will:
1. Understand how comparing the inflammatory predictors of disease in people with treated HIV to those in the general population can help us identify interventional targets that are particularly relevant for people with HIV.
2. Appreciate how genetics studies can help us understand what inflammatory pathways are most relevant in contributing to disease risk in people with treated HIV.
3. Be aware of the many ways asymptomatic CMV appears to affect the immune system in people with treated HIV.

Accreditation Statement:

This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of the Medical Society of the State of New York (MSSNY) and the Physicians’ Research Network (PRN). MSSNY is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing Medical Education for physicians.

The Medical Society of the State of New York designates this live activity for a maximum 2.0 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

ABIM MOC Recognition Statement:

Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 2 Medical Knowledge MOC points in the American Board of Internal Medicine’s (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider’s responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit.

Disclosure Statements:

Policies and standards of the Medical Society of the State of New York and the Accreditation Council for Continuing Medical Education require that speakers and planners for continuing medical education activities disclose any relevant financial relationships they may have with commercial interests whose products, devices, or services may be discussed in the content of a CME activity.
- Dr. James F. Braun (Course Director/Program Planner) has no relevant financial relationships to disclose.
- Dr. Joseph P. McGowan, MD (Moderator) has no relevant financial relationships to disclose.
- Dr. Anil K. Chaturvedi, Ph.D. (Presenter) has no relevant financial relationships to disclose. Dr. Chaturvedi will submit his slides in advance for adequate peer review and will support his presentation and clinical recommendations with the best available evidence from the medical literature.
- Dr. Scott A. Roof, MD MS (Presenter) TBA. Dr. Roof will submit his slides in advance for adequate peer review and will support his presentation and clinical recommendations with the best available evidence from the medical literature.
- Dr. Peter W. Hunt, MD (Presenter) TBA. Dr. Hunt will submit his slides in advance for adequate peer review and will support his presentation and clinical recommendations with the best available evidence from the medical literature.

Financial Support:

This PRN CME activity is funded in part by unrestricted educational grants from Gilead Sciences and ViiV Healthcare and by a generous charitable contribution from Northwell Health Center for AIDS Research & Treatment.